This study is in its 2nd Phase. It focuses on the evaluation of Topical Non-Steroidal anti-inflammatory drugs with a non-central involved DME. The clinical criteria is to assess the effects of NSAIDs on macular retinal volume compared with placebo in eyes with non-central DME. The principle investigator is John S Pollack, MD at will take place at our Joliet office and Barb as the head coordinator. Please contact our Joliet office for more information.